Two new terpenoid ester glycosides from the twigs of Litsea cubeba

Abstract

A new sesquiterpenoid ester glycoside (1) and a new monoterpenoid ester glycoside (2) have been isolated from an ethanol extract of the twigs of Litsea cubeba. Their structures were elucidated by extensive 1D- and 2D-NMR experiments, and the absolute configurations were determined by chemical methods, specific rotation, and a combination of experimental and theoretically calculated electronic circular dichroism spectra. Compound 1 exhibited selective cytotoxicity against A549 and HCT-8 cell lines with the IC₅₀ values of 8.9 and 9.6 μM, respectively.

Keywords:

• Lauraceae
• Litsea cubeba
• sesquiterpenoid ester glycoside
• monoterpenoid ester glycoside
• cytotoxicity

Disclosure statement

No potential conflict of interest was reported by the authors.

Supplementary material

Supplementary data associated with this article, including, ¹H NMR spectrum of compound 1a, 1D, and 2D NMR spectra of compounds 1 and 2 can be found in the online version.

Additional information

Funding

The project’s financial support from the National Natural Science Foundation of China (NNSFC) [grant numbers 81522050, 81773589], the National Science and Technology Project of China [grant number 2018zx09711001-001], the CAMS Innovation Fund for Medical Science (CIFMS) [grant number 2017-I2M-3-010], Key projects of the Beijing Natural Sciences Foundation and Beijing Municipal Education Committee [grant number KZ201811417049], and the Science and Technology program of Qinghai [grant number 2018-ZJ-739] is acknowledged.