Wuchuyuamide V, a new amide alkaloid from the fruits of Tetradium trichotomum

Abstract

Tetradium trichotomum Lour., is a plant species endemic to tropical South East Asia with particular medicinal importance. However, very little analysis in this plant has been studied up to now from a phytochemical viewpoint. One new amide alkaloid (wuchuyuamide V, 1), as well as two known amide alkaloids-wuchuyuamide III (2), and wuchuyuamide I (3) were obtained from the fruits of T. trichotomum for the first time. The structures of wuchuyuamide V (1) and wuchuyuamide III (2) were unambiguously elucidated by 1D and 2D-NMR spectra, mass spectrometry, and single-crystal X-ray diffraction.

Graphical Abstract

Keywords:

• Wuchuyuamide V
• Tetradium trichotomum Lour.
• amide alkaloids
• Rutaceae
• Evodia

Disclosure statement

The authors declare that there are no conflicts of interest.

Funding

This work was financially supported by the National Natural Science Foundation of China [Grants No 31470425 and 31570359], the Science and Technology Foundation of Jiangsu Province [Grant No BM2015019], and the Social Development Projects from the Science and Technology Foundation of Jiangsu Province [grant No BE2016753].