Two new iridoid glycosides from Callicarpa nudiflora

Abstract

Two new iridoid glycosides, callicoside E (1) and callicoside F (2), were isolated from the leaves of Callicarpa nudiflora. Their structures were established by one- and two-dimensional NMR spectroscopy and mass spectrometry. In an in vitro bioassay, compounds 1 and 2 showed an pronounced hepatoprotective activity against d-galactosamine-induced toxicity in WB-F344 rat hepatic epithelial stem-like cells.

Keywords:

• Verbenaceae
• Callicarpa nudiflora
• iridoid glycosides
• hepatoprotective activity

Acknowledgements

We thank Professor Ai-Hong Liu at Center of Analysis And Testing Nanchang University for NMR measurements.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

Financial support was provided by the National Natural Science Foundation of China (NSFC, Grant Nos. 81373955 and 81460589).