Abstract
Eighteen uronic acid derivatives were designed and synthesized, and the cytotoxicities in vitro of two cancer cell lines (BEL7402 and SGC7901) were evaluated by MTT assay. The results showed that the inhibitory rate of the compounds on both cell lines was significantly higher than the parent compound. The IC50 of compounds II4, II6, III4, and III6 are comparable or stronger than the positive control drug, the interactions between compounds II4, II6, III4, III6, and NF-κB were also studied by docking simulations.
Acknowledgments
We thank Shenyang Pharmaceutical University for the tool and technology assistance in docking studies.
Disclosure statement
No potential conflict of interest was reported by the authors.
Funding
This work was supported by the National Natural Science Foundation of China [21372156]; the Liaoning University Innovation Team Support Project [LT2017009]; the Liaoning Province key R & D project [2019JH2 /10300034]; and the Key projects of Shenyang University of Chemical Technology [LDB2019001].
Figure 2. Binding modes of compound II4 with NF-κB in 3D and 2D diagram. The H-bond interactions with compounds are shown in green, alkyl-bonds are shown in pink, and sulfur-bonds are shown in yellow.
![Figure 2. Binding modes of compound II4 with NF-κB in 3D and 2D diagram. The H-bond interactions with compounds are shown in green, alkyl-bonds are shown in pink, and sulfur-bonds are shown in yellow.](/cms/asset/6eb82ddb-829b-4ada-bd95-8cef638c6618/ganp_a_1571488_f0002_c.jpg)
Figure 3. Binding modes of compound II6 with NF-κB in 3D and 2D diagram. The H-bond interactions with compounds are shown in green, and alkyl-bonds are shown in pink.
![Figure 3. Binding modes of compound II6 with NF-κB in 3D and 2D diagram. The H-bond interactions with compounds are shown in green, and alkyl-bonds are shown in pink.](/cms/asset/0ad8319a-6a9b-4df0-b4a9-8444c5a0815e/ganp_a_1571488_f0003_c.jpg)
Correction Statement
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