Advanced search
Publication Cover
Journal of Asian Natural Products Research Volume 22, 2020 - Issue 4
Submit an article Journal homepage
269
Views
6
CrossRef citations to date
0
Altmetric
Articles

Two novel non-holostane type glycosides from the viscera of sea cucumber Apostichopus japonicus

Xuan-Ming ZhangKey Laboratory for Drug Screening Technology & Key Laboratory for Biosensors, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan250103, China;
,
Li-Wen HanKey Laboratory for Drug Screening Technology & Key Laboratory for Biosensors, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan250103, China;
,
Wen-Long ShengKey Laboratory for Drug Screening Technology & Key Laboratory for Biosensors, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan250103, China;
,
Xiao-Bin LiKey Laboratory for Drug Screening Technology & Key Laboratory for Biosensors, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan250103, China;
,
Shan-Shan ZhangKey Laboratory for Drug Screening Technology & Key Laboratory for Biosensors, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan250103, China;
,
Jing-Lan GuoKey Laboratory for Drug Screening Technology & Key Laboratory for Biosensors, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan250103, China;
,
Hou-Wen LinResearch Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai200127, China
&
Ke-Chun LiuKey Laboratory for Drug Screening Technology & Key Laboratory for Biosensors, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan250103, China; Correspondence[email protected]
 show all
Pages 329-337 | Received 25 Nov 2018, Accepted 28 Jan 2019, Published online: 13 Jun 2019
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

Abstract

Two novel glycosides, apostichoposide A1 (1) and B1 (2), were isolated from the viscera of Chinese sea cucumbers (Apostichopus japonicus, Selenka) collected in the Bohai sea. Both the isolated glycosides were characterized by non-holostane type aglycones having 18(16)-lactone and 7(8)-double bond. Cytotoxic activities of the two compounds were evaluated against three human cancer cell lines. Compound 1 had adequate cytotoxic activity against MGC-803 and PC-3M cell lines. Our results indicated that glycosides present in A. japonicus viscera are an important high value resource for biotechnological applications.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Funding

This study was financially supported by the Public Science and Technology Research Funds Projects of Ocean (grant number 201505030), the National Natural Science Foundation of China (grant number 81602982), and the Shandong Natural Science Foundation of China (grant number ZR2016YL009).

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 426.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.