Abstract
Seven natural compounds, including new compounds hyperascyrins L-N (1-3) and four known compounds (4-7), were acquired from the aerial parts of Hypericum ascyron, that were all identified as methylated polycyclic polyprenylated acylphloroglucinol derivatives (mPPAPs). The structures of these compounds were established by NMR spectroscopy, experimental and calculated electronic circular dichroism (ECD) data. The neuroprotective activities and hepatoprotective activity of these compounds (10 µM) were evaluated. Compounds 1, 2 and 3 exhibited neuroprotection activity. Compounds 1 and 3 show hepatoprotective activity.
Graphical Abstract
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Acknowledgments
The authors thank Prof. Wen-Yi He, Prof. Xiang-Ju Jin, Prof. Ying Peng, and Prof. Hua Sun for providing the NMR spectra and for performing the bioassays.
Disclosure statement
No potential conflict of interest was reported by the authors.