Two new ent-abietane diterpenoids from Euphorbia helioscopia

Abstract

Two new ent-abietane diterpenoids, euphcopenoids A (1) and B (2), along with six known analogues (3 – 8), were isolated from the whole plants of Euphorbia helioscopia. Their structures were determined by various spectroscopic methods (MS, UV, IR, and NMR), and the absolute configurations of compounds 1 and 2 were determined by quantum chemical ECD calculations. All compounds were screened for the cytotoxicity against A549 and HEPG2 cancer cell lines, but were inactive.

Keywords:

• Euphorbiaceae
• Euphorbia helioscopia
• ent-abietane diterpenoids

Acknowledgments

We cordially thank Dr. You-Kai Xu at Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, for his help with the plant identification.

Disclosure statement

No potential conflict of interest was reported by the authors.