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Journal of Asian Natural Products Research Volume 22, 2020 - Issue 9
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A new bile acid from the traditional chinese medicine shedan

Yan Yuana Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan430030, ChinaView further author information
,
Qiu-Yan Wanga Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan430030, ChinaView further author information
,
Jie Zhanga Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan430030, ChinaView further author information
,
Jing Nieb Hubei Institute for Drug Control, Wuhan430075, ChinaView further author information
,
Cheng-Gao Zhoua Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan430030, ChinaView further author information
,
Wen-Qin Yia Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan430030, ChinaView further author information
,
Luo-Sheng Wana Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan430030, ChinaCorrespondence[email protected]
View further author information
&
Jia-Chun Chena Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan430030, ChinaCorrespondence[email protected]
View further author information
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Pages 879-885 | Received 08 Feb 2019, Accepted 12 Aug 2019, Published online: 19 Sep 2019
 
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Abstract

A new bile acid tauro-16β-hydroxy-12α-sulfate-5β-cholenoic acid (1), along with six known ones (2–7), was isolated from the snake bile. Its planar structure and relative configuration were elucidated based on extensive spectroscopic analyses. Moreover, compound 2 showed inhibitory effect on NO production in RAW 264.7 macrophages at non-cytotoxic concentration (20 μM) with inhibitory rate of 69.7%.

Disclosure statement

No competing financial interest was reported by the authors.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China [grant number 31870330, 81373917 and 81773869].

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