Alkaloids from the aerial parts of Leptopyrum fumarioides express immunomodulatory activity

Abstract

A new type aporphine-benzylisoquinoline alkaloid leptofumarine (1) was isolated from Leptopyrum fumarioides L. The structure of 1 was elucidated based on spectroscopic evidence. Leptofumarine together with the previously isolated leptopyrine (2) were evaluated for their effect on macrophages and bone marrow (BM) cells in vitro. Both alkaloids inhibited cytokine production by LPS-stimulated peritoneal macrophages. Leptopyrine suppressed osteoclast and osteoblast formation, while leptofumarine affected only osteoblastogenesis.

Keywords:

• Leptopyrum fumarioides
• leptofumarine
• leptopyrine
• cytokines
• osteoclastogenesis

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by International Scientific Project between Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences and Institute of Chemistry and Chemical Technology, Mongolian Academy of Sciences.