Polyketides with quorum sensing inhibitory activity from the marine-derived fungus Aspergillus sp. ZF-79

Abstract

Seven compounds were isolated from a marine-derived fungus Aspergillus sp. ZF-79, including three new polyketides (1–3), named asperochrins D-F, along with four known compounds 4–7. Their structures were determined on the basis of spectroscopic methods. All the compounds were tested for quorum sensing inhibitory (QSI) activity. Compounds 1, 3, 4, 5, and 6 exhibited QSI activity against Chromobacterium violaceum CV026 with MIC values of 50, 100, 50, 50, and 6.25 μM, respectively.

Keywords:

• Aspergillus sp.
• polyketides
• quorum sensing inhibitory activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by Key Research& Development Program of Hainan Province (ZDYF2019127), Natural Science Foundation of China (41606088), Financial Fund of the Ministry of Agriculture and Rural Affairs, China (NFZX2018), Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences (17CXTD-15, 1630052016008), and Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).