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Abstract
Three new polyketides including two benzophenone derivatives, penibenzones A and B (1 and 2), and a new phthalide derivative, penibenzone C (3), along with six known compounds, were isolated from the solid-substrate cultures of the endophytic fungus Penicillium purpurogenum IMM003. Their structures were elucidated on the basis of spectroscopic data (UV, IR, HRESIMS, 1D and 2D NMR). All compounds were evaluated for inhibitory activity against pancreatic lipase, but none of them displayed activity.
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was financially supported by the National Natural Science Foundation of China (NNSFC; nos. 81803397 and 81522050), the Science and Technology program of Qinghai (Grant No. 2018-ZJ-739), the Drug Innovation Major Project (Grant Nos. 2018ZX09711001-001, and 2018ZX09711001-008), the Special Research Fund for Central Universities, Peking Union Medical College (Grant No. 3332018088) and the Innovation Platform Construction Project of Qinghai Province (Grant No. 2017-ZJ-Y19).