Two new sesquiterpenes from cultures of the fungus Irpex lacteus

Abstract

Two new tremulane-type sesquiterpenes, irlactin L (1) and irlactin M (2) were isolated from cultures of the fungus Irpex lacteus, together with one known compound, 6-hydroxy-2,6-dimethyloct-7-enoic acid (3). Their structures were elucidated by spectroscopic data analysis. Compounds 1–2 were tested for their cytotoxicities against five human cancer cell lines and for their inhibitory activities against isozymes of 11β-hydroxysteroid dehydrogenases (11β-HSD).

Graphical Abstract

Keywords:

• Irpex lacteus
• fugnus
• secondary metabolite
• tremulane sesquiterpene

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This project was financially supported by the First-rate Discipline (Education) Construction Project of the Higher Education Institutions of Ningxia [NXYLXK2017B11], China, the Ningxia Normal University Research Grant [NXSFZDA1904], the Natural Science Foundation of Ningxia, China [2019AAC03245], the Key Research Foundation of Ningxia, China [2019BDE03009], the “Domestic Talent 312 Program” of Ningxia, China [NDB2018.139], the Guyuan Science and Technology Support Program [2018GYYQ0007, 2019GKGY039], the National Natural Science Foundation of China [31760090], the Program for Innovation Talents of Science and Technology in Ningxia, China [KJT2015005], Youth Talent Cultivation Project in Ningxia, China [NXRS2017(279)], the Guyuan Talent Support Program [2019GYSZZB1202] and Engineering and Technology Research Center of Liupanshan Resources Grant [HGZD19-02], Ningxia Normal University, China.