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Journal of Asian Natural Products Research Volume 23, 2021 - Issue 4
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Original Articles

One new sesquiterpene pyridine alkaloid from the stems and leaves of Euonymus fortunei

Guang-Kai Kuanga Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou510632, ChinaView further author information
,
Lin Wangb Analytical and Testing Center, Jinan University, Guangzhou510632, ChinaView further author information
,
Li-Li Yangb Analytical and Testing Center, Jinan University, Guangzhou510632, ChinaView further author information
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Yu-Bo Zhanga Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou510632, China;c Department of Pharmacology, School of Medicine, Jinan University, Guangzhou510632, ChinaView further author information
,
Ding Luoa Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou510632, ChinaView further author information
,
Yi-Duo Zhoua Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou510632, ChinaView further author information
,
Neng-Hua Chena Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou510632, ChinaView further author information
,
Zhong-Nan Wua Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou510632, ChinaView further author information
,
Guo-Cai Wanga Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou510632, China;d International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), School of Pharmacy, Jinan University, Guangzhou510632, ChinaCorrespondence[email protected]
View further author information
&
Yao-Lan Lia Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou510632, China;d International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), School of Pharmacy, Jinan University, Guangzhou510632, ChinaCorrespondence[email protected]
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Pages 399-406 | Received 05 Dec 2019, Accepted 09 Apr 2020, Published online: 22 Apr 2020
 
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Abstract

A new sesquiterpene pyridine alkaloid (1), along with four known compounds (2-5), were isolated from the stems and leaves of Euonymus fortunei. The new structure was determined by extensive spectroscopic analyses (IR, UV, NMR, HRESIMS and ECD). In addition, compound 3 showed a stronger anti-respiratory syncytial virus (RSV) activity with an IC50 value of 1.20 ± 0.10 µM than the positive control ribavirin with an IC50 value of 5.62 ± 0.49 µM.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by grants from the National Key R&D Program of China (No. 2017YFC1703800), Natural Science Foundations of China (Nos. 81803376, 81673319, and 81673670), Science and Technology Planning Project of Guangzhou City (Nos. 201904010447, 201707010399), Natural Science Foundation of Guangdong Province (No. 2018B030311020, 2017A030313732), China Postdoctoral Science Foundation (No. 2019T120795), and Science and Technology Planning Project of Shenzhen City (JCYJ20170818162249554).

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