Cytotoxic jatrophane diterpenoids from the aerial parts of Euphorbia helioscopia

Abstract

A phytochemical study of 80% ethanol extract from the aerial parts of Euphorbia helioscopia led to the isolation of three new jatrophane diterpenoids, euphoheliphanes A-C (1–3). Their structures were established on the basis of spectroscopic data (NMR, IR, UV, and MS). The isolated diterpenoids were tested in vitro for cytotoxic potentials against 6 renal cancer cell lines. As a result, compounds 1–3 exhibited some cytotoxic activities against all the tested tumor cell lines with IC₅₀ values less than 50 μM.

Graphical Abstract

Keywords:

• Euphorbia helioscopia
• Euphorbiaceae
• jatrophane diterpenoids
• cytotoxic activity

Disclosure statement

No potential conflict of interest was reported by the authors.