Cytotoxic steroidal glycosides from the underground parts of Hosta ventricosa

Abstract

A phytochemical study on the underground parts of Hosta ventricosa yielded one new spirostanol saponin (1), two new furostanol saponins (2 and 3), and one new pregnane glycoside (4), along with three known compounds (5‒7). Their structures were elucidated on the basis of chemical and spectroscopic analysis. All isolated compounds were evaluated for their cytotoxic effects against five human cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW-480). Compounds 1, 2, and 5‒7 showed cytotoxic activities with IC₅₀ values of 3.21-17.06 μM.

Graphical abstract

Keywords:

• Hosta ventricosa
• steroidal saponins
• pregnane glycoside
• cytotoxic activities

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This study was financially supported by the National Natural Science Foundation of China (31260084) and the Scientific Research Fund of Jiangxi Provincial Education Department (GJJ150769).