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Journal of Asian Natural Products Research Volume 23, 2021 - Issue 6
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A new dilignan from the twigs and leaves of Archidendron clypearia

Yu-Xi WangKey Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, ChinaView further author information
,
Zhi-Kang DuanKey Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, ChinaView further author information
,
Wan-Yi ShiKey Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, ChinaView further author information
,
Ye ChangKey Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, ChinaView further author information
,
Xiao-Xiao HuangKey Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-0099-1118View further author information
ORCID Icon &
Shao-Jiang SongKey Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9074-2467View further author information
ORCID Icon
Pages 609-614 | Received 30 Dec 2019, Accepted 27 Jun 2020, Published online: 09 Jul 2020
 
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Abstract

Previous work has shown that the lignans from the twigs and leaves of Archidendron clypearia (Jack) I.C.N. possess anti-β-amyloid aggregation activity. Here we report a new dilignan, archidendronin A (1), along with one known sesquilignan (2). Their structures were determined by extensive spectroscopic methods, including UV, HRESIMS, 1 D and 2 D NMR data. The inhibitory activity on Aβ1-42 aggregation was screened by ThT assay with curcumin as the positive control, and compounds 1 and 2 showed inhibition rate of 60.0% and 64.4% at 20 μM, respectively.

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Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China (81502954) and the Career Development Support Plan for Young and Middle-aged Teachers in Shenyang Pharmaceutical University (ZQN2018006) and the Project of Innovation Team Foundation (LT2015027).

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