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Journal of Asian Natural Products Research Volume 23, 2021 - Issue 9
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Chemical constituent with cytotoxicity from Sterculia diversifolia

Fazle Rabbia Department of Pharmacy, Abasyn University Peshawar, Peshawar, Khyber Pakhtunkhwa25000, PakistanCorrespondence[email protected]
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,
Amir Zadab Department of Pharmacy, University of Peshawar, Peshawar, Khyber Pakhtunkhwa25120, PakistanView further author information
,
Achyut Adhikaric Central Department of Chemistry, Tribhuvan University, Kritipur, Kathmandu44600, NepalCorrespondence[email protected]
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,
Amna Nisarb Department of Pharmacy, University of Peshawar, Peshawar, Khyber Pakhtunkhwa25120, PakistanView further author information
&
Saifullah Khan Khalilb Department of Pharmacy, University of Peshawar, Peshawar, Khyber Pakhtunkhwa25120, PakistanView further author information
Pages 899-905 | Received 09 Jan 2020, Accepted 27 Jun 2020, Published online: 11 Jul 2020
 
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Abstract

One new coumarin (stercularin), along with eleven known compounds, was isolated for the first time from ethyl acetate fraction of Sterculia diversifolia. The structures of isolated compounds were characterized by spectroscopic techniques such as EIMS, 1H-NMR and 13C-NMR. Compound 1 showed significant cytotoxicity by brine shrimp lethality assay (LD50: 8.00 μg/ml) and PC-3 cell lines protocol (IC50: 3.92 ± 0.20 μg/ml), respectively.

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Disclosure statement

We declare that we have no conflict of interest.

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Funding

This study was self-funded.

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