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Abstract
In this work, we isolated and characterized fusapyrone A (1), a new γ-pyrone derivative, along with six previously described compounds from the rice fermentation of Fusarium sp. CPCC 401218, a fungus collected from the desert. The structure of 1 was characterized using various spectroscopic analyses, such as MS, IR, 1D, and 2D NMR. The absolute configuration of 1 was determined through the use of 13C NMR chemical shifts, electronic circular dichroism (ECD) and optical rotation (OR) calculations. Compound 1 was found to have weak antiproliferative activity for Hela cells, with an IC50 of 50.6 μM.
Graphical Abstract
Disclosure statement
The authors have no potential conflicts of interest to report.
Additional information
Funding
This work was made possible due to financial support from the National Natural Science Foundation of China (grant no. NNSFC 81302675), CAMS Innovation Fund for Medical Sciences (grant no. CIFMS 2016-I2M-2-002 and 2018-I2M-3-005), the Drug Innovation Major Project of China (Grant Nos. 2018ZX09711001-007 and 2018ZX09735001-002), and National Infrastructure of Microbial Resources (grant no. NIMR 2020-3).