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Journal of Asian Natural Products Research Volume 23, 2021 - Issue 10
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Research Article

Strepyrazinone, a tricyclic diketopiperazine derivative with cytotoxicity from a marine-derived actinobacterium

Lu Zhanga School of Pharmacy, Binzhou Medical University, Yantai 264003, ChinaView further author information
,
Ling-Ling Fenga School of Pharmacy, Binzhou Medical University, Yantai 264003, ChinaView further author information
,
Guang-Fei Wangb College of Life Sciences, Yantai University, Yantai 264005, ChinaView further author information
,
Qiao-Li Yangb College of Life Sciences, Yantai University, Yantai 264005, ChinaView further author information
,
Xin-Zhen Fua School of Pharmacy, Binzhou Medical University, Yantai 264003, ChinaView further author information
,
Zhi Lia School of Pharmacy, Binzhou Medical University, Yantai 264003, ChinaView further author information
,
Ming Liua School of Pharmacy, Binzhou Medical University, Yantai 264003, ChinaView further author information
,
Li-Juan Koua School of Pharmacy, Binzhou Medical University, Yantai 264003, ChinaView further author information
,
Bo Xub College of Life Sciences, Yantai University, Yantai 264005, ChinaView further author information
,
Ze-Ping Xiea School of Pharmacy, Binzhou Medical University, Yantai 264003, China;c Shandong International Biotechnology Park, Yantai 264670, ChinaView further author information
,
Shu-Min Zhanga School of Pharmacy, Binzhou Medical University, Yantai 264003, China;c Shandong International Biotechnology Park, Yantai 264670, ChinaView further author information
&
Lin Guoa School of Pharmacy, Binzhou Medical University, Yantai 264003, ChinaCorrespondence[email protected]
View further author information
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Pages 968-974 | Received 20 Mar 2020, Accepted 10 Jul 2020, Published online: 21 Aug 2020
 
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Abstract

Strepyrazinone (1), a tricyclic diketopiperazine derivative with a carbon skeleton unprecedented in natural products, was isolated from the marine-derived Streptomyces sp. B223. Its structure was elucidated by spectroscopic analyses and electronic circular dichroism calculation. Compound 1 showed cytotoxic activity against HCT-116 cancer cell lines with an IC50 value of 0.34 µM.

Graphical abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research was funded by Natural Science Foundation of Shandong Province, grant number ZR2018LD006 and Shandong Province Key Scientific and Technical Problem, grant number 2014GHY115010.

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