Constituents of Aegle marmelos from Myanmar

Abstract

Five compounds (1–5), including three coumarins (1–3) and two alkaloids (4,5) were isolated during the first investigation of the stem bark of Aegle marmelos (L.) Corrêa. collected in Myanmar. Their structures were determined by NMR spectra analysis. Among them, 7´-O-ethylmarmin (1) and 2-O-ethyltembamide (5) were identified as new compounds. Skimmianine (4) showed moderate cytotoxicity against a HeLa cell line, and 7´-O-ethylmarmin (1), marmin (2), and (+)-epoxyaurapten (3) displayed weak radical scavenging activity according to a DPPH scavenging assay.

Graphical abstract

Keywords:

• Aegle marmelos
• Rutaceae
• coumarins
• cytotoxicity
• radical scavenging activity

Acknowledgements

This work was financially supported by the bounty for academic research from the Research Institute of Meijo University. One of the authors (H.T.A.) is supported by Daiko Foundation Research Fellowship Program 2016.

Disclosure statement

No potential conflict of interest was reported by the authors.