Chemical constituents from the dish-cultured Antrodia camphorata and their cytotoxic activities

Abstract

One new meroterpenoid, antroquinonol Y (1), a new ergostane-type sterol, antcamphin Y (2), and a new ergostane-type triterpenoid, antcamphin Z (3), together with 10 known ones (4–13), were isolated from the dish-cultured fungus Antrodia camphorata. Their structures were characterized by extensive NMR and HRESIMS data analyses. The absolute configurations were elucidated by experimental and calculated electronic circular dichroism (ECD) spectral analyses and chemical semi-synthesis. Compounds 1, 3, and 5 exhibited potent inhibitory activities against four human cancer cell lines (U251, HL60, SW480, and A549 cells) with IC₅₀ values of 4.6 to 11.7 μM.

Graphical Abstract

Keywords:

• Antrodia camphorata
• Polyporaceae
• meroterpenoid
• sterol
• ergostane-type triterpenoid
• cytotoxic activities

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the National Key Research and Development Program of China (grant no. 2017YFC1700405), the National Natural Science Foundation of China (grant no. 81725023), Beijing Natural Science Foundation (grant no. JQ18027), and the National Mega-project for Innovative Drugs (grant no. 2018ZX09711001-008-003).