Two new quinochalcone glycosides from the safflower yellow pigments

Abstract

Two new quinochalcone glycosides, hydroxysafflor yellow A-4'-O-β-D-glucopyranoside (1) and 3'-hydroxyhydroxysafflor yellow A (2), were isolated from the safflower yellow pigments of Carthamus tinctorius. The structures of new compounds were elucidated by a detailed spectroscopic analysis (UV, IR, HR-ESI-MS, 1D and 2D NMR, ECD). The in vitro assay indicated that compound 1 could improve the survived rate of primary mouse cortical neurons on glutamate-induced neurons damage model at a concentration of 10 μM.

Graphical Abstract

Keywords:

• Asteraceae
• Carthamus tinctorius
• safflower yellow pigments
• neuroprotective
• quinochalcone glycosides
• hydroxysafflor yellow A-4'-O-β-D-glucopyranoside
• 3'-hydroxyhydroxysafflor yellow A

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research was financially supported by the Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (No.2017-I2M-3-010) and the National Natural Science Foundation of China (No. 81673311).