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Journal of Asian Natural Products Research Volume 23, 2021 - Issue 11
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Research Article

A new homo-aro-cholestane glycoside from the rhizome of Paris polyphylla var. chinensis

Liang-Jun Guana National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China; View further author information
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Li-Shuai Dinga National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China; ;b School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaView further author information
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Yan-Min Lia National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China; View further author information
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Liang-Mian Chena National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China; View further author information
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Hui-Min Gaoa National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China; Correspondence[email protected] [email protected]
View further author information
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Zhi-Min Wanga National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China; Correspondence[email protected] [email protected]
View further author information
&
Zhu-Ju Wanga National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China; View further author information
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Pages 1107-1114 | Received 18 Jun 2020, Accepted 04 Nov 2020, Published online: 23 Nov 2020
 
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Abstract

A new homo-aro-cholestane glycoside parispolyside H, along with nine known compounds, were isolated from 75% ethanolic extract of the rhizome of Paris polyphylla var. chinensis. Their chemical structures were elucidated on the basic of analysis of detailed spectroscopic and physicochemical properties. In addition, the isolated compounds (1, 6-9) were evaluated for their cytotoxic activity against HepG2 human liver cancer cell lines. Among them, four known compounds (6-9) showed cytotoxicity with IC50 values ranging from 0.41 to 3.6 μM.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by National Key R&D Program of China (Grant No. 2017YFC1701900), National Standardization Project of Traditional Chinese Medicine (Grant No. ZYBZH-Y-FJ-09), and the Special Scientific Research Projects in Traditional Chinese Medicine Industry (Grant No. 201507002).

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