Paresordin A, a new diphenyl cyclic peroxide from the lichen Parmotrema praesorediosum

Abstract

From the lichen Parmotrema praesorediosum, one new diphenyl peroxide, named praesordin A (1), together with four depsidones, including virensic acid (2), protocetraric acid (3), 8'-O-methylprotocetraric acid (4), and furfuric acid (5) were purified. Their structures were chacracterized using extensive HR-ESI-MS and NMR spectroscopic methods. The isolated compounds (2-5) possessed stronger α-glucosidase inhibitory activity (IC₅₀ = 43.7-110.1 μM) than the standard drug acarbose (IC₅₀ = 214.5 μM).

Graphical Abstract

Keywords:

• Parmotrema praesorediosum
• Parmeliaceae
• diphenyl peroxide
• depsidone
• α-glucosidase inhibitory activity

Acknowledgments

The authors would like to thank Dr. Thi-Phi-Giao Vo, Department of Biology, University of Science, University of Science, National University HCM City, Vietnam for the authentification of the scientific name for the studied species.

Disclosure statement

No potential conflict of interest was reported by the authors.