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Journal of Asian Natural Products Research Volume 24, 2022 - Issue 4
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Alternatones A and B, two polyketides possessing novel skeletons from entophyte Alternaria alternate L-10

Xuan ZhangState Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing210023, ChinaView further author information
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Xian-Xian LiuState Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing210023, ChinaView further author information
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Yin-Nan XingState Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing210023, ChinaView further author information
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Mei ZhangState Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing210023, ChinaView further author information
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Yang ZhaoState Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing210023, ChinaView further author information
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Yuan-Yuan WeiState Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing210023, ChinaView further author information
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Bo ZhangState Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing210023, ChinaCorrespondence[email protected] [email protected]
View further author information
&
Rui-Hua JiaoState Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing210023, ChinaCorrespondence[email protected] [email protected]
View further author information
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Pages 353-360 | Received 06 Feb 2021, Accepted 24 May 2021, Published online: 18 Jun 2021
 
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Abstract

On our ongoing searching for bioactive natural products derived from entophytes, two polyketides possessing novel skeletons, alternatones A–B (1–2), were identified from the culture of Alternaria alternate L-10. Their structures were established by a combination of spectroscopic and single-crystal X-ray diffraction with Cu Ka radiation. Alternatone A (1) exhibited cytotoxic activity against human hepatoma carcinoma HepG-2 cell line. The putative biosynthetic pathways for compounds 1–2 were also proposed.

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Disclosure statement

These authors have no conflict of interest to declare.

Additional information

Funding

This work was financially supported by MOST of China (2018YFA0902000, 2018YFC1706200 and 2019YFC0312500), Jiangsu Provincial Research Foundation for Basic Research, China (Grant No. BK 20180333), the National Natural Science Foundation of China (81903483).

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