Natural bioactive compounds from marine fungi (2017–2020)

Abstract

Secondary metabolites generated by marine fungi have relatively small molecular weights and excellent activities and have become an important source for developing drug lead compounds. The review summarizes the structures of novel small-molecule compounds derived from marine fungi in recent years; introduces representative monomers in antimicrobial, antitumor, anti-viral, and anti-neuritis aspects; and discusses their biological activities and molecular mechanisms. This review will act as a guide for further discovering marine-derived drugs with novel chemical structures and specific targeting mechanisms.

Graphical Abstract

Keywords:

• Marine fungi
• secondary metabolites
• antimicrobial
• antitumor
• anti-virus
• anti-neuritis

Disclosure statement

The authors declare no conflict of interest.

Figure 1. Chemical structures of antimicrobial compounds (1-20).

Figure 2. Chemical structures of antimicrobial compounds (21-40).

Figure 3. Chemical structures of antimicrobial compounds (41-55).

Figure 4. Chemical structures of antimicrobial compounds (56-67).

Figure 5. Chemical structures of antitumor compounds (68-87).

Figure 6. Chemical structures of antitumor compounds (88-102).

Figure 7. Chemical structures of antitumor compounds (103-118).

Figure 8. Chemical structures of anti-neuritis compounds (119-145).

Figure 9. Chemical structures of antivirus compounds (146-164).

Figure 10. Chemical structures of other biological compounds (165-180).

Table 1. List of compounds isolated from marine fungi with potential biological activity.

Additional information

Funding

This work was financially supported by the supporting fund for teachers’ research of Jining Medical University (Nos. JYFC2018KJ026, JYFC2018KJ027, JYFC2018KJ047), natural science foundation of Hebei Province of China (No. B2019402020), and national training programs of innovation and entrepreneurship for undergraduates (No. 201810443037).