Selective obstruction of the mTORC2 complex by a naturally occurring cholestane saponin (OSW-1) for inhibiting prostate cancer cell growth

Abstract

Ornithogalum caudatum Ait (OCA) is a natural product used in Chinese traditional medicine. The cholestane saponin OSW-1 is isolated from plant OCA and has recently been shown to have potent cytotoxic effects against different types of cancers. The therapeutic efficacy of OSW-1 on prostate cancer and its underlying mechanism are yet to be established. OSW-1 inhibited the growth of prostate cancer cells by interrupting the interaction between mTOR and Rictor/mTORC2. This mechanism showed a better therapeutic outcome than that of the conventional inhibition of mTOR and provided a basis for as sisting modern prostate cancer treatment strategies.

Keywords:

• Prostate cancer
• OSW-1
• mTORC1
• mTORC2

Acknowledgments

Nanjing Sky Technology Co. Ltd. for supporting this study.

Disclosure statement

The author declares no conflict of interest.

Funding

This study was supported by Nanjing Sky Technology Co. Ltd [AG/NST001].

Data availability

All presented data in this research are included in the study.

Additional information

Funding

This study was supported by Nanjing Sky Technology Co. Ltd [AG/NST001].