A new bioactive isocoumarin from the mangrove-derived fungus Penicillium sp. TGM112

Abstract

A new isocoumarin, penicimarin N (1), along with five known compounds (2-6), were isolated from the mangrove-derived fungus Penicillium sp. TGM112. The structure of 1 was elucidated on the basis of extensive spectroscopic data analysis, and the absolute configuration of 1 was determined by comparison of their circular dichroism (CD) spectra with the literature. The structures of known compounds were determined by comparison with the literature data. All the isolated compounds were examined for their antioxidant and α-glucosidase activities. Compound 1 showed strong antioxidant activity with the IC₅₀ value of 1.0 mM, and 1 also exhibited moderate inhibitory activity against α-glucosidase with the IC₅₀ value of 620 μM.

Keywords:

• Mangrove plant
• Pencillium sp.
• isocoumarin
• bioactivity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the Key Research and Development Program of Hainan Province (No. ZDYF2019183), National Natural Science Foundation of China (No. 31760093), Hainan Provincial Natural Science Foundation of China (No. 220RC593).