Two new dinor-eudesmane sesquiterpenoids from the roots of Chloranthus multistachys

Abstract

Two new dinor-eudesmane sesquiterpenoids, named multistalin A (1), and multistalin B (2), together with three sesquiterpene glycosides (3–5), and a norlabdane-type diterpene (6) were isolated from the root extract of Chloranthus multistachys Pei. Their structures were elucidated on the basis of spectroscopic analysis including 1D, 2D NMR techniques and HR-ESI-MS. In addition, the cytotoxicity activities of the isolated compounds against selected cancer cells (Hela and A-549) were evaluated by MTT assay.

Graphical Abstract

Keywords:

• Chloranthaceae
• Chloranthus multistachys
• sesquiterpenoids
• cytotoxicity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China (No. 82073807), Natural Science Foundation of Shaanxi Province (No. 2019JM-203), and Key Research and Development Program of Gansu Baicao Herbal Medicine Biotechnology Co., Ltd. (No.2019BC710049).