https://orcid.org/0000-0003-2885-4545
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Abstract
A new ent-kaurane diterpenoid, named kaurane daturoside A (1), was isolated from the 70%-EtOH extract of dried pericarps of Datura metel L., along with six known terpenoids, 16α,17-dihydroxy-ent-kauran-19-diglycoside (2), cyclosieversioside F (3), astragaloside II (4), ginsenoside Rg1 (5), astrojanoside A (6), celerioside E (7). The isolated structures were elucidated by means of spectroscopic analyses, and the compounds 2, 3, 7 were separated from Solanaceae for the first time. Meanwhile, among isolates, compounds 2 and 5 exhibited anti-inflammatory activities against LPS-activated RAW264.7 cells (IC50<11.00 μM).
Graphical Abstract
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This research work was financially supported by the National Natural Science Foundation of China (NSFC) (81773883, 81903781); National Key Research and Development Project (2018YFC1707100); China Postdoctoral Science Foundation (2018M631978); Excellent Youth Project of Heilongjiang Natural Science Foundation (YQ2019H029); Heilongjiang University of Chinese Medicine Founds (2018pt01, 2018bs03); Innovative Research Project for graduate students of Heilongjiang University of Chinese Medicine (2020yjscx009).