Synthesis, antitumor and antibacterial activities of cordycepin derivatives

Abstract

Twelve novel cordycepin derivatives were designed and synthesized with modification at positions of 2′, 5′-hydroxyl and N⁶ amino groups of cordycepin. The results showed that the inhibitory activities of 3, 4b, 6c and 6d on A549 were comparable to the positive control gefitinib, and the inhibitory activity of 6a on A549 was better than that of gefitinib. Also, the inhibitory activities of twelve cordycepin derivatives against E. coli 1924, S. aureus 4220 and S. mutans 3289 were studied. Among them, 4b showed certain inhibitory on S. mutans 3289, while 6b showed certain inhibition on S. aureus 4220.

Graphical Abstract

Keywords:

• Synthesis
• cordycepin
• nucleosides
• antitumor activity
• antibacterial activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China [No. 81760627].