Abstract
A novel series of 1-substituted phenazines 4a-4l were designed and synthesized via Palladium-catalyzed reactions from 1-phenazine trifluoromethanesulfonate. These phenazines showed antichlamydial activity with IC50 values from 1 to 10 μM. Among them, compounds 4c and 4i exhibited the best antichlamydial activity with IC50 values from 2.06 to 2.74 μM without apparent cytotoxicity to host cells.
Graphical Abstract
![](/cms/asset/f9afe1e1-fb44-42b6-9503-621e70ac9f19/ganp_a_1982909_uf0001_c.jpg)
Disclosure statement
No potential conflict of interest was reported by the authors.