Two new stilbene glucosides and a new benzoic acid derivative from Tournefortia sibirica

Abstract

Two new stilbene glucosides, trans-3,5-dihydroxy-4-methoxystilbene 3-O-β-D-glucopyranoside (1), cis-3,5-dihydroxy-4-methoxystilbene 3-O-β-D-glucopyranoside (2), one new benzoic acid derivative, cis-4-hydroxy-3-hydroxymethyl-2-butenyl benzoate 4-O-β-D-glucopyranoside (3), and four known compounds (4 − 7) were isolated from Tournefortia sibirica L. The structures of these compounds were elucidated on the basis of spectral data. Anti-inflammatory effects of compounds (1 − 7) were evaluated in terms of inhibition on production of NO, TNF-α and IL-6 in LPS-induced RAW 264.7 cells. Compounds 1, 2 and 5 − 7 could inhibit the levels of NO, TNF-α and IL-6 in LPS-induced RAW264.7 cells with IC₅₀ values ranging from 40.96 to 88.76 µM.

Graphical Abstract

Keywords:

• Boraginaceae
• Tournefortia sibirica
• stilbene glucosides
• benzoic acid derivative
• anti-inflammatory activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research was financially supported by the National Natural Science Foundation of China (No. 81760627). This research was also financially supported by the Department of Science & Technology of Jilin Province (No. 20200201034JC), Education Department of Jilin Province (No. JJKH20200534KJ), and Administration of traditional Chinese Medicine of Jilin Province (No. 2020140).