One new phenylpropanoid glycoside from Myxopyrum smilacifolium with α-glucosidase inhibitory activity

Abstract

One new phenylpropanoid glycoside, myxosmoside I (1) and six known compounds, arenarioside (2), verbacoside (3), 3-formylindole (4), 5-hydroxymethyl furfural (5), D-manitol (6), and glycerol monooleate (7) were isolated from the roots of Myxopyrum smilacifolium (Wall.) Blume. Their chemical structures were determined by 1D-, 2D-NMR, and mass spectra, chemical methods, and compared with those reported in the literature. All compounds were evaluated for α-glucosidase inhibitory effect. Among them, phenylpropanoid glycosides 1–3 significantly inhibited α-glucosidase activity with IC₅₀ values of 30.0 ± 0.9, 66.6 ± 2.3, and 36.9 ± 2.0 µM, respectively.

Graphical Abstract

Keywords:

• Myxopyrum smilacifolium
• Oleaceae
• phenylpropanoid glycoside
• myxosmoside
• α-glucosidase

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The authors are grateful for the Institute of Marine Biochemistry’s financial support under grant number HSB20-TN01.