Abstract
Six new secondary metabolites, including two new nor-triterpenes (1 and 2), one new sesquiterpene (4), two new α-pyrone derivatives (6 and 7), and one new natural product (5) along with two known compounds (3 and 8) were isolated from an endophytic fungus Colletotrichum gloeosporioides obtained from a toxic medicinal plant Tylophora ovata. Their structures were elucidated by spectroscopic data analyses, while their absolute configurations were determined by CD and X-ray diffraction analyses. The in vitro anti-inflammatory activities of these compounds were evaluated.
Graphical Abstract
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Acknowledgments
We are grateful to the Department of Instrumental Analysis, Institute of Material Medica, Chinese Academy of Medical Sciences & Peking Union Medical College for measuring the IR, NMR, MS and HRESIMS.
Disclosure statement
No potential conflict of interest was reported by the authors.