One novel naphthalene derivative and other constituents with anti-complementary activities from the aerial parts of Dracocephalum moldavica

Abstract

One novel naphthalene derivative, 2-octa-2′,4′,6′-atriynenaphthalene (1), together with eighteen known compounds (2–19) were isolated from the aerial parts of Dracocephalum moldavica L. Compounds 2, 8, 10, 13, 15–17 and 19 were obtained from the family Lamiaceae for the first time, and compounds 11 and 18 were firstly identified from the genus of Dracocephalum. All the isolates were evaluated for anti-complementary activities through the classical and alternative pathways, and the targets of the most active compounds on the complement activation cascade were also investigated.

Graphical Abstract

Keywords:

• Dracocephalum moldavica
• Lamiaceae
• naphthalene
• anti-complementary activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China (NSFC) under Grant number 81760627. This work was also supported by the Jilin Provincial Education Department (JJKH20200534KJ).