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Abstract
Five new Erythrina alkaloids and five known E. alkaloids were isolated from a 95% ethanol extract of the stems of Erythrina corallodendron L. Their chemical structures were elucidated by UV, IR, HRESIMS, NMR and X-ray. Furthermore, the analgesic activities of E. alkaloids 1, 2 and 6 were evaluated by using an acetic acid-induced writhing test in mice, and their writhing inhibition rates were 67.9%, 64.6% and 70.3% at doses of 20 mg/kg, respectively.
Graphical Abstract
Acknowledgment
We are grateful to the Department of Instrumental Analysis, Institute of Material Medica, Chinese Academy of Medical Sciences & Peking Union Medical College for performing the IR spectroscopy, NMR spectroscopy, MS and HRESIMS.
Disclosure statement
No potential conflicts of interest were reported by the authors.
Additional information
Funding
This work was financially supported by the National Natural Science Foundation of China (No. 21732008).