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Articles

Expeditious assembly of biuret-guanidine derivatives via the catalyst-free transformation

, , , , , , & ORCID Icon show all
Pages 259-267 | Received 10 Mar 2021, Accepted 06 Jan 2022, Published online: 24 Jan 2022
 

Abstract

We disclose a mild and practical catalyst-free transformation for the expeditious construction of biuret-guanidine derivatives using aromatic isocyanates. This synthetic transformation is featured with mild reaction conditions and high efficiency.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China (81602977), the CAMS Basic and Innovation Fund for Medical Sciences (2019-RC-HL-010 and 2017-I2M-1-013), the Science and Technology Development Project of Jilin Province of China (20190304050YY).

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