A new sesquiterpenoid juvenile hormone III from the stems of Cananga latifolia

Abstract

A new juvenile hormone III, canangalia I (1), along with six known juvenile hormone III analogues (2–7), was isolated from the methanolic extract of Cananga latifolia stems. All structures were elucidated using spectroscopic data and compared with data from previous literature. Canangalia I (1) was found to be cytotoxic against human cervical adenocarcinoma (HeLa) cells with an IC₅₀ value of 35.00 ± 2.15 µg/ml after 72 h, but was not toxic to Vero cells.

Graphical Abstract

Keywords:

• Cananga latifolia
• Annonaceae
• juvenile hormone III
• cervical adenocarcinoma
• cytotoxicity

Acknowledgements

R. Phatchana acknowledges the Thailand Research Fund (TRF) and the Commission on Higher Education (CHE) through grant number MRG6080093, and the Faculty of Engineering, Rajamangala University of Technology Isan, Khon Kaen campus for financial support. We are thankful to the Natural Product Research Unit of the Department of Chemistry, Faculty of Science, Khon Kaen University.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the Thailand Research Fund (TRF), the Commission on Higher Education (CHE) (grant number MRG6080093), and the Faculty of Engineering, Rajamangala University of Technology Isan, Khon Kaen campus.