Limonoids from the fruits of Chisocheton lasiocarpus (Meliaceae)

Abstract

Two new azadirone-type limonoids, namely lasiocarpine A (1) and lasiocarpine B (2) were isolated from the fruit of Chisocheton lasiocarpus along with three known limonoids (3–5). UV, IR, one- and two- dimensional NMR, and mass spectrometry were used to determine the chemical structure of the isolated compounds. Furthermore, their cytotoxic activity against breast cancer cell line MCF-7 was evaluated using PrestoBlue reagent. From these compounds, lasiocarpine A (1) showed the strongest activity with an IC₅₀ value of 43.38 μM.

Graphical Abstract

Keywords:

• Chisocheton lasiocarpus
• limonoid
• lasiocarpine
• cytotoxic activity
• MCF-7 cell line

Acknowledgements

We thank to Mr. Kansi Haikal and Ms. Nurul Fadhilah at the Central Laboratory, Universitas Padjadjaran University for HRTOF-MS measurements and cytotoxic assay.

Disclosure statement

No potential conflict of interest was reported by the authors.