Schisanwilsonins H and I, two new dibenzocyclooctane lignans from the fruits of Schisandra wilsoniana

Abstract

Two new dibenzocyclooctane lignans, schisanwilsonins H (1) and I (2), together with eight known compounds gomisin J (3), wulignan A₁ (4), gomisin S (5), tigloylgomisin P (6), gomisin O (7), (-)-gomisin K₁ (8), rubschisantherin (9) and wuweizisu C (10) were isolated from the 95% ethanol extract of the fruits of Schisandra wilsoniana. 7 exhibited anti-HBV activity with potency against HBsAg and HBeAg secretion by 37.1% and 32.6%, respectively, at 50 μg/ml. 10 exhibited anti-HIV activity with EC₅₀ and therapeutic index (TI) values of 2.10 μg/ml and 11.98, respectively.

Graphical Abstract

Keywords:

• Schisandraceae
• Schisandra wilsoniana
• dibenzocyclooctane lignan
• schisanwilsonin H
• schisanwilsonin I

Acknowledgment

The authors are grateful to Prof. Kuo-Hsiung Lee for anti-HIV bioassay during his worktime at University of North Carolina at Chapel Hill for anti-HIV bioassay during his lifetime.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China (30925042, 30271586).