Combinatorial biosynthesis: playing chess with the metabolism

Abstract

Secondary metabolites are a group of natural products that produced by bacteria, fungi and plants. Many applications of these compounds from medicine to industry have been discovered. However, some changes in their structure and biosynthesis mechanism are necessary for their properties to be more suitable and also for their production to be profitable. The main and most useful method to achieve this goal is combinatorial biosynthesis. This technique uses the multi-unit essence of the secondary metabolites biosynthetic enzymes to make changes in their order, structure and also the organism that produces them.

Graphical Abstract

Keywords:

• combinatorial biosynthesis
• secondary metabolites
• natural products
• genome
• genetic engineering

Disclosure statement

No potential conflict of interest was reported by the authors.