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Journal of Asian Natural Products Research Volume 25, 2023 - Issue 3
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Research Articles

First total syntheses of kanjone and its natural analogues

Min Wua Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, School of Pharmacy, Chengdu University, Chengdu610106, China;b School of Food and Biological Engineering, Chengdu University, Chengdu610106, ChinaView further author information
,
Li-Jia Xua Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, School of Pharmacy, Chengdu University, Chengdu610106, ChinaView further author information
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Ying Lia Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, School of Pharmacy, Chengdu University, Chengdu610106, ChinaView further author information
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Pei Yua Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, School of Pharmacy, Chengdu University, Chengdu610106, ChinaView further author information
,
Lan Lua Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, School of Pharmacy, Chengdu University, Chengdu610106, ChinaView further author information
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Shi-Ting Xieb School of Food and Biological Engineering, Chengdu University, Chengdu610106, China;c Engineering Research Center for Engineering Pharmaceuticals and Equipments of Sichuan Province, School of Pharmacy, Chengdu University, Chengdu610106, ChinaView further author information
,
Yu-Jiao Hec Engineering Research Center for Engineering Pharmaceuticals and Equipments of Sichuan Province, School of Pharmacy, Chengdu University, Chengdu610106, ChinaView further author information
&
Hong-Bo Donga Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, School of Pharmacy, Chengdu University, Chengdu610106, China;b School of Food and Biological Engineering, Chengdu University, Chengdu610106, ChinaCorrespondence[email protected] [email protected]
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Pages 277-286 | Received 24 Feb 2022, Accepted 08 Apr 2022, Published online: 19 Apr 2022
 
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Abstract

Kanjone (1), a bioactive furanoflavone and a potent biomolecule, was first isolated from Pongamia pinnata (L.). Herein, we have developed two approaches to synthesize kanjone as well as its natural analogues 6-methoxyisopongaglabol (2) and 6,3'-dimethoxy-[2″,3″:7,8]furanoflavone (3) starting from khellin and 3-hydroxy-4-methoxy-benzaldehyde, respectively.

Graphical Abstract

Disclosure statement

The authors report there are no competing interests to declare.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China (number 82003619) and the Open Research Fund of Key Laboratory of Coarse Cereal Processing of Ministry of Agriculture and Rural Affairs (number 2021CC006).

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