Acuminatums E and F, two new cyclic lipopeptides from Fusarium lateritium HU0053 and their antifungal activity

Abstract

Two new cyclic lipopeptides, acuminatums E (1) and F (2), together with four known cyclic lipopeptides, acuminatums A–D (3–6) were isolated from the corn culture of endophytic Fusarium lateritium HU0053. Their structures were elucidated by spectroscopic and advanced Marfey's amino acid analysis. All compounds were found to exhibit antifungal activities against Penicillium digitatum. Acuminatum F (2), a new cyclic lipopeptide containing an unusual 3, 4-dihydroxy-phenylalanine unit exhibited the strongest antifungal activities with inhibition zone of 6.5 mm at the dose of 6.25 μg. Therefore, acuminatum F might be a potential environmental-friendly preservative for citrus fruits.

Graphical Abstract

Keywords:

• Fusarium lateritium HU0053
• cyclic lipopeptides
• acuminatum compounds
• Penicillium digitatum

Disclosure statement

The authors declare that they have no conflicts of interest.

Additional information

Funding

This work was financially supported by the National Science Foundation of China (31772032), State Key Laboratory of Applied Microbiology Southern China (SKLAM006-2015) and Special Funds for the Cultivation of Guangdong College Students' Scientific and Technological Innovation (Climbing Program Special Funds, pdjh2020b0567).