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Journal of Asian Natural Products Research Volume 25, 2023 - Issue 4
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Articles

3,6'-Disinapoylsucrose alleviates the amyloid precursor protein and lipopolysaccharide induced cognitive dysfunction through upregulation of the TrkB/BDNF pathway

Yun-Ting Wanga Beijing Key Laboratory of Bioactive Substances and Functional Foods, Institute of Functional Food Science and Technology, Beijing Union University, Beijing100023, China;b Department of Food Science, School of Biochemical Engineering, Beijing Union University, Beijing100191, ChinaView further author information
,
Han Wangb Department of Food Science, School of Biochemical Engineering, Beijing Union University, Beijing100191, ChinaView further author information
,
Wu-Jiang Renb Department of Food Science, School of Biochemical Engineering, Beijing Union University, Beijing100191, ChinaView further author information
,
Xue-Ling Daia Beijing Key Laboratory of Bioactive Substances and Functional Foods, Institute of Functional Food Science and Technology, Beijing Union University, Beijing100023, ChinaView further author information
,
Qing Huob Department of Food Science, School of Biochemical Engineering, Beijing Union University, Beijing100191, ChinaView further author information
,
Shuo Wangc Department of Food Science, Nankai University School of Medicine, Tianjing300350, ChinaView further author information
&
Ya-Xuan Suna Beijing Key Laboratory of Bioactive Substances and Functional Foods, Institute of Functional Food Science and Technology, Beijing Union University, Beijing100023, ChinaCorrespondence[email protected]
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Pages 387-402 | Received 05 Dec 2021, Accepted 20 Apr 2022, Published online: 07 Jun 2022
 
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Abstract

The aim of this study is to explore the effect and mechanism of 3,6’-disinapoylsucrose (DISS) on an Alzheimer's disease (AD) mice model induced by APPswe695 lentivirus (LV) and intraperitoneal injection of lipopolysaccharide (LPS). The results show that DISS improves cognitive ability, decreases the levels of IL-2, IL-6, IL-1β, and TNF-α, reduces the expression of NF-κB p65, and alleviates Aβ deposition and nerve cell damage. DISS can regulate tyrosine kinase B (TrkB)/brain-derived neurotrophic factor (BDNF) signaling in the hippocampus. In summary, DISS can significantly alleviate neuroinflammation, spatial learning and memory disorders in AD model mice.

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Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

National Natural Science Foundation of China [grant number 11975048]; Beijing Union University Open Project [grant number SWHX202103]; Beijing Union University Scientific Research Project Funding [grant number XP202007].

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