Antitumor potential of tricyclic pyridone analogues from an entomopathogenic fungus, Fusarium avenaceum SYKC02-P-1

Abstract

Two new tricyclic pyridone analogues, fusapyridons C (1) and D (2), were isolated along with structurally related known compounds 3 − 5 from the entomopathogenic fungus, F. avenaceum SYKC02-P-1. The structures of compounds 1 and 2 were elucidated by analyzing the spectral data of UV, 1 D and 2 D NMR as well as HRESIMS. The absolute configurations of fusapyridons C and D were established by means of single crystal X-ray diffraction and electronic circular dichroism calculation. And antitumor testing of all the isolates showed that compounds 4 and 5 exhibited significant inhibitory activity against the human prostate cancer cells (PC-3 cell lines) with IC₅₀ values of 2.76 and 1.86 μM, respectively.

Graphical Abstract

Keywords:

• Pyridone analogues
• entomopathogenic fungus
• Fusarium avenaceum
• structure elucidation
• cytotoxicity

Acknowledgements

We are grateful to Mr. Jian Hao from the Department of Analytical Testing Center, Beijing University of Chemical Technology, for the test of X-ray diffraction.

Disclosure statement

No potential conflict of interest was reported by the authors.

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Funding

The author(s) reported there is no funding associated with the work featured in this article.