Strepolyketide D, a new SEK15-derived polyketide compound from salt-lake-derived Streptomyces sp. DBC5

Abstract

A new SEK15-derived polyketide compound, strepolyketide D (1), was isolated from salt-lake-derived Streptomyces sp. DBC5, together with two known analogues (2-3). Their structures were elucidated based on spectroscopic analysis of IR, MS, 1 D and 2 D NMR. Compound 2 elicited moderate antioxidation with IC₅₀ value of 39.26 μg/ml. The results of the study revealed that salt-lake actinomycetes of Lake Dabancheng appear to have immense potential as a source of polyketide compounds.

Graphical Abstract

Keywords:

• Streptomyces sp.
• polyketide
• antioxidant activity
• strepolyketide D

Acknowledgments

Special thanks to Ma Zhongjun's research group from Marine College of Zhejiang University and Zhang Zhidong's research group from Institute of Microbial Application of Xinjiang Academy of Agricultural Sciences for their support and help.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by NSFC Joint Fund (grant number U1903101) and Science and Technology Innovation Key Cultivation project of XAAS (Xinjiang Academy of Agricultural Sciences) (Xjkcpy-202203).