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Journal of Asian Natural Products Research Volume 25, 2023 - Issue 3
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Research Articles

Alkaloids from the stem of Ephedra equisetina

Deng-Hui Zhua School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou450046, China;b Key Research Laboratory of the Substance Basis of Chinese Medicinal Effects, The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou450046, ChinaView further author information
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Jing-Ke Zhanga School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou450046, China;b Key Research Laboratory of the Substance Basis of Chinese Medicinal Effects, The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou450046, ChinaView further author information
,
Ju-Fang Jiaa School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou450046, China;b Key Research Laboratory of the Substance Basis of Chinese Medicinal Effects, The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou450046, ChinaView further author information
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Juan-Juan Liua School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou450046, China;b Key Research Laboratory of the Substance Basis of Chinese Medicinal Effects, The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou450046, ChinaView further author information
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Jun-Jun Weia School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou450046, China;b Key Research Laboratory of the Substance Basis of Chinese Medicinal Effects, The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou450046, ChinaView further author information
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Meng Yanga School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou450046, China;b Key Research Laboratory of the Substance Basis of Chinese Medicinal Effects, The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou450046, ChinaView further author information
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Ying Yanga School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou450046, China;b Key Research Laboratory of the Substance Basis of Chinese Medicinal Effects, The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou450046, ChinaView further author information
,
Meng Lia School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou450046, China;b Key Research Laboratory of the Substance Basis of Chinese Medicinal Effects, The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou450046, ChinaView further author information
,
Zhi-You Haoa School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou450046, China;b Key Research Laboratory of the Substance Basis of Chinese Medicinal Effects, The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou450046, ChinaView further author information
,
Xiao-Ke Zhenga School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou450046, China;b Key Research Laboratory of the Substance Basis of Chinese Medicinal Effects, The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou450046, China;c Chinese Medicine R&D Department, Co-Construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of China, Zhengzhou450046, ChinaView further author information
&
Wei-Sheng Fenga School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou450046, China;b Key Research Laboratory of the Substance Basis of Chinese Medicinal Effects, The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou450046, China;c Chinese Medicine R&D Department, Co-Construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of China, Zhengzhou450046, ChinaCorrespondence[email protected]
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Pages 238-244 | Received 23 Mar 2022, Accepted 09 May 2022, Published online: 25 May 2022
 
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Abstract

Two new cyclotrypyamine alkaloids equisetinines A and B, as well as three known alkaloids (3–5) were isolated from the stems of Ephedra equisetina Bunge. Their structures were characterized by spectroscopic methods, and the absolute configurations of the new compounds were determined by interpretation of their electronic circular dichroism. Anti-asthmatic activities of compounds were evaluated by releasing β-Hex in C48/80-induced RBL-2H3 cells, and compound 5 exhibited significant anti-asthmatic activities.

Graphical Abstract

Disclosure statement

The authors have declared that there is no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article.

Additional information

Funding

This research was financially supported by The National Key Research and Development Project (The Major Project for Research of the Modernization of TCM, No. 2019YFC1708800).

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