A new cyclic peptide from Selaginella tamariscina

Abstract

A new cyclic peptide selapeptin B (1), together with one known nor-lignan glycoside moellenoside C (2), was isolated from Selaginella tamariscina. The structures of 1 and 2 were elucidated on the basis of chemical and spectral analysis, including 1D, 2D NMR analyses and HRESIMS. Two compounds were evaluated for cytotoxic activities against B16F10, MDA-MB-231, and MDA-MB-468 cell lines by MTT assay. Compound 1 showed the potent activity against B16F10 melanoma cell lines.

Graphical Abstract

Keywords:

• Selaginellaceae
• Selaginella tamariscina
• selapeptin B
• moellenoside C
• cytotoxicity

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

This work was financially supported by the Key Research and Development Plan of Heilongjiang Province (No. GZ20210092), the University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province (No. 2020CX30) and General Project of Teaching Reform Research in Provincial Higher Education (No. SJGY20200350).