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Abstract
A new chromone analog (1) and a new pyrrole alkaloid (2), together with four known compounds, were isolated from the endophytic fungus Penicillium sclerotiorum MPT-250 obtained from the stems of Taxus wallichiana var. chinensis (Pilger) Florin. The structural elucidation of these metabolites was performed by high-resolution mass spectrometry and NMR spectroscopy. Compounds 1 and 5 exhibited significant antibacterial activity against carbapenems-resistant Pseudomonas aeruginosa and multidrug-resistant Enterococcus faecium with an minimum inhibitory concentration (MIC) value of 3.13 μg/ml respectively.
Graphical Abstract
Disclosure statement
Authors declare no conflict of interest.
Additional information
Funding
This work was financially supported by the National Natural Science Foundation of China (Nos. 81872755, 82073714, and 31900288), the National Key R&D Program of China (2020YFC1712703), the National Civil Affairs Commission´s young and middle-aged talents training program (MZR20008), the Fundamental Research Funds for the Central Universities, South-Central University for Nationalities (YZZ20009), the Key Project at Central Government Level: The ability establishment of sustainable use for valuable Chinese medicine resources (2060302), and the Fundamental Research Funds for the Provincial Universities of Zhejiang (2021TD001).